NTU team redefines uranium-234 half-life, opening new horizons for Earth science and human history

Dr. Hsun-Ming Hu, a postdoctoral researcher of the Department of Geosciences, National Taiwan University (NTU), along with an international team led by NTU’s Distinguished Professor Shen Chuan-Chou, has made a significant advancement in geochronology by redefining the half-life of uranium-234 with remarkable accuracy. This new measurement extends the range of uranium-thorium dating from 600 to 800 thousand years (ka), greatly enhancing the precision in understanding Earth's climate history and human evolution. This paper was published on October 1, 2025, in the journal Science Advances (1). The uranium-thorium dating method determines…

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Unraveling the Mechanism of DNA Repair: Single-Molecule Study Reveals How Accessory Proteins Shape RAD51 Filament Assembly

A new interdisciplinary study, recently published in Nucleic Acids Research (2025), uncovers how accessory proteins influence the growth of protein filaments essential for DNA repair. The research, led by Prof. Hung-Wen Li (Department of Chemistry) and Prof. Peter Chi (Institute of Biochemical Sciences), combines expertise in biophysics and biochemistry to investigate how RAD51, an enzyme central to homologous recombination, assembles on DNA during repair. Their collaboration reflects a growing trend of bridging the physical and life sciences to understand complex cellular mechanisms. A key challenge in studying filament-forming proteins like…

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International Collaboration Team Reveals Key Mechanism in Regulating DNA Recombination

Meiotic recombination generates genetic diversity and promotes proper chromosomal segregation of parental chromosomes. This process requires a set of recombinases polymerized on single-stranded (ss)DNAs called the nucleoprotein filament to undergo homology search and strand exchange between homologous DNAs. In Saccharomyces cerevisiae meiosis, programmed DNA double-strand breaks (DSBs) are formed by Spo11 to generate 3’-ssDNA tails. Once formed, ssDNA overhangs are rapidly bound by the abundant high-affinity ssDNA-binding protein, Replication protein A (RPA), to protect these ssDNAs from nucleolytic degradations or formation of the higher-order DNA structures. RPA-coated ssDNA substrates are…

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Unveiling the Hottest Period in a Million Years: The “MIS 11c Paradox”

By Prof. Chuan-Chou Shen, Dept. of Geosciences  Over millions of years, Earth has experienced cycles of ice ages and warm periods. Today, we find ourselves in a warm period heavily influenced by human activities. As greenhouse gas levels in the atmosphere rise, global warming intensifies, causing ice sheets to melt rapidly, sea levels to rise, and posing severe threats to global ecosystems and human societies. Understanding the mechanisms behind these warming periods by studying past extreme warm periods is a crucial task for modern scientists. The hottest warm period in…

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Mie-tronics under microscopy

Since a millennium ago, it is well known that grinding metals yields various colors, presented as the beautiful colored windows in churches or the famous Lycurgus Cup. However, the underlying physics was not elucidated until Gustav Mie developed the corresponding electromagnetic wave scattering theory in the early 20th century. The Mie theory explains how structuring metals to sizes comparable to light wavelengths, not much smaller nor much larger, creates new optical resonances, enhancing absorption/scattering of specific wavelengths, and producing vivid colors. In the 21st century, the nanoscale Mie resonance phenomenon has been…

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Exciting Discovery Reveals Link Between Deep-Sea Fish and Changing Seawater Temperatures

In a groundbreaking interdisciplinary research effort spanning over three years, a team of talented scientists has unveiled a significant breakthrough. Assistant Research Fellow Dr. Chien-Hsiang Lin from the Biodiversity Research Center at Academia Sinica, along with Assistant Professor Dr. Li Lo from the Department of Geological Sciences at National Taiwan University, and Associate Professor Dr. Chih-Lin Wei and Assistant Professor Dr. Sze Ling Ho from the Institute of Oceanography at National Taiwan University, have made a remarkable discovery. Their findings shed light on the intricate relationship between the structure of…

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Anticipating the occurrence and type of critical transitions

Chun-Wei Chang and Chih-hao Hsieh Prof. Chih-hao Hsieh from the Institute of Oceanography and Prof. Chun-Wei Chang from the Institute of Fishery Sciences, NTU lead an international team and develop a novel method that successfully anticipates the occurrence and type of a variety of critical transition events. This study, published in Science Advances (Jan 2023), overcomes the long-lasting challenge in revealing a quantitative threshold as well as distinguishing types of critical transition by early warning signals using empirical data collected in real-world systems. The proposed method also provides a powerful…

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Split westerly winds over Europe – A breakthrough by an international project led by Department of Geosciences

Europe, even located at the mid-high latitude at 40-70oN, the autumn and winter are mild and comfortable. Such pleasant weather is regulated by the warm and humid westerly winds from the North Atlantic Ocean. During the 15th to 19th century, Europe experienced the coldest winters over the last ten thousand years, known as the “Little Ice Age” (LIA). The LIA was suggested to be caused by volcanic eruptions and low solar activity. However, the detailed climate pattern in Europe remains unclear.Dr. Hsun-Ming Hu, the first author, and Prof. Chuan-Chou Shen,…

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Prof. Chih-hao Hsieh and his collaborators publish “ Causal networks of phytoplankton diversity and biomass are modulated by environmental context” paper in “Nature Communications”

Causal networks of phytoplankton diversity and biomass are modulated by environmental context Chun-Wei Chang and Chih-hao Hsieh Postdoctoral fellow, Dr. Chun-Wei Chang, from the National Center for Theoretical Sciences and Prof. Chih-hao Hsieh from the Institute of Oceanography, NTU lead an international research team and analyze aquatic ecosystems (ranging from lake, river to estuary and ocean) around the world to unveil key causal interactions and feedbacks between biodiversity, ecosystem functions, and various environmental factors. This study, published in Nature Communications (March 3, 2022), overcomes the long-lasting challenge in quantifying complex…

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Exploring global pollution and cycling of mercury using ocean migratory fish

Profs. Chun-Mao Tseng and Jen-Chieh Shiao from the Institute of Oceanography, NTU, and the US cooperative colleagues worked together as the mercury research team (referred to Team Mercury (Hg) hereinafter). The research provides them to initiate a new tool of the mercury accumulation rate (MAR) using top predators to examine global patterns in the cycling and pollution of Hg across the world's oceans. It also confirms the unchanging truth of "You are what you eat, and You have what you are" since time began. The results of this study, published…

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